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Sterol Bionsynthesis Inhibitors (Ellis Horwood Series in Biomedicine)

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Published by Wiley-VCH .
Written in English

Subjects:

  • Biochemistry,
  • Agricultural science,
  • Biomedical engineering,
  • Pharmacology,
  • Science

Book details:

The Physical Object
FormatHardcover
Number of Pages583
ID Numbers
Open LibraryOL12765856M
ISBN 103527267441
ISBN 109783527267446

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Sterol Biosynthesis Inhibitors. Karl‐Heinz Kuck. Pastor‐Löh‐Str. 30a, Langenfeld, Germany. Search for more papers by this author. Klaus Stenzel. Book Editor(s): Dr. Wolfgang Krämer. Rosenkr Burscheid, Germany. Search for more papers by this by: ISBN: OCLC Number: Description: pages: illustrations. Contents: Part I: Chemistry, Mode of Action, Toxicology, and General Aspects of Sterol Biosynthesis Inhibitors; Chemistry of Sterol Biosynthesis Inhibitors: Piperazines, Pyridines, Pyrimidines, Imidazoles, l,2,4-Triazoles, Morpholines, Piperidines, Allylamines; . A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid hormones. They may inhibit the production of cholesterol and other sterols, sex steroids such as androgens, estrogens, and progestogens, corticosteroids Biological target: Steroidogenic enzymes. 2. Comparison of the Sterol Biosynthesis Pathways in Mammals, Fungi, and Trypanosomatids. A comparative schematic diagram of the sterol biosynthesis pathway in eukaryotes is shown in Figure least 20 metabolic steps are necessary to synthesize such sterols as cholesterol and ergosterol, with some steps involving specific enzymes that differ between mammalian cells and microorganisms .

Sterol Biosynthesis Inhibitors Secondary Effects and Enhanced in Vivo Efficacy DIETER BERG. Bayer AG Monheirn Research Center Leverkusen, Federal Republic of Germany Inhibitors of Fungal Sterol Synthesis: Squalene-Epoxidation and CDemethylation, Journal of Enzyme Inhibition, /, 3. Sterol biosynthesis is one of the few areas of difference in primary metabolism between fungi and animals. Unlike animals that synthesize desalkyl sterols, such as cholesterol (cholesten-3β-ol), many pathogenic fungi synthesize alkylsterols, such . INTRODUCTION. Most eukaryotic cells contain and synthesize sterols. Whereas cholesterol is the unique sterol of vertebrates and ergosterol the major sterol of most fungi and some unicellular algae, most higher plants contain a complex mixture in which cholesterol is a minor component and ethyl sterols (sitosterol and stigmasterol) account for more than 60% and methyl sterols account for. The mechanism of each of the reactions in the post-squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.

Allenic analogues (1) and (2) of fucosterol (9) and desmosterol (11) were synthesized and the former was found to be a specific inhibitor of sterol metabolism in the silkworm. Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds (Chemistry of Plant Protection (1)) Softcover reprint of the original 1st ed. Edition by G. Haug (Author) ISBN ISBN Why is ISBN important? ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a Author: 敏郎 加藤, G. Haug, H. Hoffman, W. S. Bowers. In the two other phenotypes (Ani R2 and Ani R3), resistance extended to various other groups of fungicide, including dicarboximides, phenylpyrroles and sterol biosynthesis inhibitors. The success of the sterol biosynthesis inhibitor (SBI) fungicides is essentially the success of the triazole fungicides. The demethylation inhibitor (DMI) fungicides are the most important mode‐of‐action class, based on their economic importance within the SBI by: